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Image Search Results
Journal: eLife
Article Title: Unique integrated stress response sensors regulate cancer cell susceptibility when Hsp70 activity is compromised
doi: 10.7554/eLife.64977
Figure Lengend Snippet: ( A ) Principal component analysis plot of publicly available RNAseq datasets is presented for tested breast cancer cell lines. MAL3-101-sensitive cells are indicated in aqua green while resistant cell lines are indicated in light red. ( B ) Heatmap representation of significantly differentially expressed proteins between publicly available RPPA datasets for sensitive and resistant cells (MDA MB 231 and MDA MB 453). Wilcoxon signed-rank test between resistant and sensitive cell lines was used to determine proteins that were differentially expressed. p<0.1 was considered significant. ( C ) Principal component analysis plot of RNAseq performed on MAL3-101 treated (Samples A4, A5, A6, B4, B5, B7 ) or DMSO (Samples A1, A2, A7, B1, B2, B3 ) treated sensitive and resistant cells. MDA MB 453 cells (MAL3-101 resistant, sample A) are represented in light red and MDA MB 231 cells (MAL3-101 sensitive, sample B) in aqua green. ( D ) The top 35 differentially expressed genes detected in MAL3-101 treated and untreated cell lines (MDA MB 231 in green and MDA MB 453 in light red) are represented in a heatmap graph. ( E ) Gene Ontology enrichment plot of Biological Processes using significantly differential genes in MDA MB 231 cell lines with and without MAL3-101 treatment. p<0.05 was considered significant.
Article Snippet: To better define the difference in the sensitivities of breast cancer cells to MAL3-101, we analyzed publicly available
Techniques: